|
gptkbp:instanceOf
|
gptkb:protein
transcription factor
|
|
gptkbp:alias
|
gptkb:TFIID_subunit_A
|
|
gptkbp:alternativeSplicing
|
produces isoforms
|
|
gptkbp:associatedWith
|
neurodegenerative disorders
spinocerebellar ataxia 17 (SCA17)
|
|
gptkbp:chromosomal_location_(mouse)
|
gptkb:chromosome_17
|
|
gptkbp:compatibleWith
|
gptkb:Bacteria
|
|
gptkbp:component
|
gptkb:TFIID_complex
|
|
gptkbp:conservedIn
|
archaea
eukaryotes
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Tjian
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:TBP_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112592
|
|
gptkbp:expressedIn
|
all tissues
|
|
gptkbp:function
|
binds to TATA box DNA sequence
initiates transcription by RNA polymerase II
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003700 (DNA-binding transcription factor activity)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TATA-box binding protein
|
|
gptkbp:interactsWith
|
gptkb:RNA_polymerase_II
gptkb:TFIIA
gptkb:TFIIB
TAFs (TBP-associated factors)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6q27_(human)
|
|
gptkbp:molecularWeight
|
~38 kDa
|
|
gptkbp:motif
|
C-terminal core domain highly conserved
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability (in some cases)
|
|
gptkbp:N-terminal_domain
|
variable among species
|
|
gptkbp:OMIM
|
600075
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
TBP (C. elegans)
TBP (fruit fly)
TBP (mouse)
TBP (yeast)
TBP (zebrafish)
|
|
gptkbp:PDB
|
gptkb:1CDW
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:RefSeq
|
NP_003188.1
|
|
gptkbp:requires
|
embryonic development
transcription initiation
cell viability
|
|
gptkbp:role
|
promoter recognition
preinitiation complex formation
basal transcription machinery
|
|
gptkbp:structure
|
saddle-shaped
|
|
gptkbp:symbol
|
gptkb:TBP
|
|
gptkbp:UniProtID
|
gptkb:P20226
|
|
gptkbp:bfsParent
|
gptkb:TBP_gene
gptkb:TATA-box_binding_protein-related_factor
|
|
gptkbp:bfsLayer
|
7
|