Sulfamethoxazole and trimethoprim
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
antibiotic combination
|
| gptkbp:ATCCode |
gptkb:J01EE01
|
| gptkbp:brand |
gptkb:Co-trimoxazole
gptkb:Bactrim gptkb:Septra |
| gptkbp:contraindication |
severe kidney disease
severe liver disease sulfa allergy pregnancy (late term) |
| gptkbp:discoveredBy |
1968
|
| gptkbp:drugClass |
sulfonamide
dihydrofolate reductase inhibitor |
| gptkbp:eliminationHalfLife |
10 hours (sulfamethoxazole)
8-10 hours (trimethoprim) |
| gptkbp:excretion |
urine
|
| gptkbp:hasComponent |
trimethoprim
sulfamethoxazole |
| https://www.w3.org/2000/01/rdf-schema#label |
Sulfamethoxazole and trimethoprim
|
| gptkbp:indication |
gptkb:toxoplasmosis
bacterial infections otitis media nocardiosis MRSA skin infection prophylaxis of pneumocystis pneumonia |
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
inhibits folic acid synthesis
|
| gptkbp:metabolism |
liver
|
| gptkbp:notEffectiveAgainst |
fungal infections
viral infections |
| gptkbp:pregnancyCategory |
D (US)
|
| gptkbp:riskFactor |
gptkb:Stevens-Johnson_syndrome
renal impairment kernicterus in neonates blood dyscrasias |
| gptkbp:routeOfAdministration |
oral
intravenous |
| gptkbp:sideEffect |
nausea
vomiting diarrhea rash photosensitivity hyperkalemia |
| gptkbp:usedFor |
gptkb:pneumocystis_pneumonia
bronchitis urinary tract infection shigellosis traveler's diarrhea |
| gptkbp:WHOModelListOfEssentialMedicines |
true
|
| gptkbp:bfsParent |
gptkb:J01EE01
|
| gptkbp:bfsLayer |
7
|