Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
Silent Information Regulator 2
YDL042C |
| gptkbp:cofactor |
NAD+
|
| gptkbp:discoveredBy |
gptkb:Leonard_Guarente
|
| gptkbp:encodes |
gptkb:NAD-dependent_histone_deacetylase
|
| gptkbp:foundIn |
gptkb:Saccharomyces_cerevisiae
|
| gptkbp:function |
epigenetic regulation
histone deacetylation |
| https://www.w3.org/2000/01/rdf-schema#label |
SIR2
|
| gptkbp:involvedIn |
gene silencing
regulation of lifespan |
| gptkbp:locatedOnChromosome |
chromosome XII (S. cerevisiae)
|
| gptkbp:memberOf |
sirtuin family
|
| gptkbp:orthologIn |
human SIRT1
|
| gptkbp:product |
Sir2p
|
| gptkbp:regulates |
transcriptional silencing at silent mating-type loci
transcriptional silencing at rDNA transcriptional silencing at telomeres |
| gptkbp:relatedTo |
aging
caloric restriction response |
| gptkbp:bfsParent |
gptkb:SIR-2
gptkb:chromosome_XII |
| gptkbp:bfsLayer |
7
|