|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
bA416N1.2
hSNAP-25
synaptosomal-associated protein, 25kDa
type 1B synaptosomal-associated protein
|
|
gptkbp:alternativeSplicing
|
produces SNAP25a and SNAP25b isoforms
|
|
gptkbp:associatedWith
|
gptkb:attention_deficit_hyperactivity_disorder
gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
|
|
gptkbp:component
|
gptkb:SNARE_complex
presynaptic active zone membrane
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Rothman
|
|
gptkbp:encodedBy
|
gptkb:SNAP25_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000132639
|
|
gptkbp:expressedIn
|
brain
pancreas
|
|
gptkbp:family
|
SNAP receptor family
|
|
gptkbp:fullName
|
gptkb:Synaptosomal-associated_protein_25
|
|
gptkbp:function
|
SNARE binding
involved in synaptic vesicle exocytosis
|
|
gptkbp:gene
|
gptkb:SNAP25
|
|
gptkbp:GOProcess
|
synaptic vesicle fusion
|
|
gptkbp:HGNC_ID
|
11132
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SNAP25
|
|
gptkbp:interactsWith
|
gptkb:VAMP2
gptkb:syntaxin-1A
STXBP1
|
|
gptkbp:length
|
206 amino acids
|
|
gptkbp:locatedOnChromosome
|
20p12.2
|
|
gptkbp:molecularWeight
|
23 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause neurological disorders
|
|
gptkbp:OMIM
|
600322
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:synaptic_vesicle_cycle
exocytosis
|
|
gptkbp:PDB
|
1KIL
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
|
|
gptkbp:proteinFamily
|
PF00957
|
|
gptkbp:RefSeq
|
NM_003081
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:role
|
neurotransmitter release
insulin secretion
|
|
gptkbp:significance
|
biomarker for synaptic function
|
|
gptkbp:structure
|
contains two SNARE motifs
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:botulinum_neurotoxin_A
gptkb:botulinum_neurotoxin_E
|
|
gptkbp:UniProtID
|
P60880
|
|
gptkbp:bfsParent
|
gptkb:SNAP-25
gptkb:VAMP1
gptkb:VAMP8
|
|
gptkbp:bfsLayer
|
7
|