|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces SNAP-25a and SNAP-25b isoforms
|
|
gptkbp:associatedWith
|
gptkb:attention_deficit_hyperactivity_disorder
epilepsy
schizophrenia
|
|
gptkbp:biologicalProcess
|
synaptic transmission
vesicle fusion
SNARE binding
syntaxin binding
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:component
|
gptkb:SNARE_complex
|
|
gptkbp:discoveredBy
|
gptkb:Richard_H._Scheller
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:SNAP25_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:SNAP25
ENSG00000132639
|
|
gptkbp:expressedIn
|
gptkb:neurons
brain
|
|
gptkbp:fullName
|
gptkb:Synaptosomal-associated_protein_25
|
|
gptkbp:function
|
regulation of neurotransmitter release
|
|
gptkbp:gene
|
gptkb:SNAP25
|
|
gptkbp:HGNC_ID
|
11132
|
|
gptkbp:interactsWith
|
gptkb:VAMP2
gptkb:synaptotagmin
gptkb:syntaxin-1
|
|
gptkbp:involvedIn
|
synaptic vesicle exocytosis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_20p12.2
|
|
gptkbp:location
|
presynaptic plasma membrane
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause neurological disorders
|
|
gptkbp:OMIM
|
600322
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1KIL
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
|
|
gptkbp:RefSeq
|
NM_003081
|
|
gptkbp:structure
|
contains two SNARE motifs
|
|
gptkbp:target
|
gptkb:botulinum_neurotoxin_A
gptkb:botulinum_neurotoxin_E
|
|
gptkbp:UniProtID
|
P60880
|
|
gptkbp:bfsParent
|
gptkb:VAMP
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SNAP-25
|