|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:INPP5D
SH2-containing inositol phosphatase 1
SH2 domain-containing phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
|
|
gptkbp:biologicalProcess
|
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
|
|
gptkbp:discoveredBy
|
T. M. Jackson et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
SH2 domain
phosphatase domain
|
|
gptkbp:encodedBy
|
INPP5D gene
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:fullName
|
Src homology 2 domain-containing inositol 5-phosphatase 1
|
|
gptkbp:function
|
phosphatase
negative regulator of PI3K signaling
|
|
gptkbp:gene
|
gptkb:INPP5D
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SHIP1
|
|
gptkbp:involvedIn
|
cell proliferation
apoptosis regulation
immune cell signaling
|
|
gptkbp:locatedOnChromosome
|
2q37.1
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
leukemia
autoimmune diseases
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:regulates
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:UniProtID
|
Q92835
|
|
gptkbp:bfsParent
|
gptkb:PI(3,4,5)P3
|
|
gptkbp:bfsLayer
|
6
|