Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
splicing factor
|
| gptkbp:code |
gptkb:splicing_factor_3_B_subunit_1
|
| gptkbp:discovered_by |
gptkb:Anthropology
|
| gptkbp:genetic_studies |
gptkb:myelodysplastic_syndromes
gptkb:Oncology |
| gptkbp:has_disease_association |
gptkb:Oncology
|
| gptkbp:has_function |
regulation of gene expression
|
| gptkbp:has_role |
RNA splicing
|
| gptkbp:has_variants |
gptkb:K700_E
R625 H S34 F |
| https://www.w3.org/2000/01/rdf-schema#label |
SF3 B1
|
| gptkbp:interacts_with |
gptkb:U2_sn_RNP
|
| gptkbp:involved_in |
pre-m RNA processing
|
| gptkbp:is_associated_with |
disease progression
genomic instability tumorigenesis chromosomal abnormalities leukemogenesis |
| gptkbp:is_essential_for |
cell viability
|
| gptkbp:is_examined_in |
clinical trials
therapeutic targets biomarker potential |
| gptkbp:is_expressed_in |
gptkb:Cell
gptkb:embryonic_development various tissues hematopoietic cells cancerous tissues |
| gptkbp:is_involved_in |
RNA metabolism
cell cycle regulation cellular stress response protein synthesis alternative splicing m RNA maturation |
| gptkbp:is_linked_to |
cell differentiation
tumor microenvironment treatment outcomes poor prognosis treatment resistance |
| gptkbp:is_part_of |
gptkb:spliceosome
RNA splicing pathway cellular machinery nuclear speckles RNA processing machinery spliceosomal complex |
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_for |
therapeutic implications
|
| gptkbp:is_studied_in |
molecular biology
cancer research |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
therapeutic agents |
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:orthologs |
other species
|
| gptkbp:bfsParent |
gptkb:myelodysplastic_syndromes
|
| gptkbp:bfsLayer |
5
|