Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activeSiteResidue |
gptkb:His41
Cys145 |
| gptkbp:alsoKnownAs |
gptkb:Mpro
main protease |
| gptkbp:discoveredIn |
2019
|
| gptkbp:EC_number |
3.4.22.69
|
| gptkbp:encodedBy |
gptkb:ORF1ab_polyprotein
|
| gptkbp:function |
cleaves viral polyproteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
SARS-CoV-2 3CL protease
|
| gptkbp:inhibitedBy |
gptkb:nirmatrelvir
gptkb:GC376 gptkb:boceprevir |
| gptkbp:locatedOnChromosome |
gptkb:SARS-CoV-2_genome
|
| gptkbp:molecularWeight |
33.8 kDa
|
| gptkbp:organism |
gptkb:COVID-19
|
| gptkbp:PDB |
gptkb:6LU7
7BQY |
| gptkbp:relatedTo |
gptkb:SARS-CoV_main_protease
|
| gptkbp:requires |
processing of viral polyproteins
|
| gptkbp:roleInVirus |
essential for viral replication
|
| gptkbp:sequenceSimilarity |
96% with SARS-CoV Mpro
|
| gptkbp:structure |
homodimer
|
| gptkbp:substrateRecognition |
Leu-Gln↓(Ser,Ala,Gly)
|
| gptkbp:target |
structure-based drug design
|
| gptkbp:targetOfDrug |
COVID-19 antivirals
|
| gptkbp:UniProtID |
P0DTD1
|
| gptkbp:bfsParent |
gptkb:PF-07321332
|
| gptkbp:bfsLayer |
7
|