Ras guanyl-nucleotide exchange factors
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:domain |
CDC25 homology domain
|
| gptkbp:example |
gptkb:RasGRF1
gptkb:RasGRP1 gptkb:RasGRP2 gptkb:RasGRP3 gptkb:RasGRP4 gptkb:SOS1 RasGEF1B |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
activate Ras proteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ras guanyl-nucleotide exchange factors
|
| gptkbp:involvedIn |
cell signaling
regulation of cell differentiation regulation of cell survival regulation of cell growth |
| gptkbp:mechanismOfAction |
facilitate exchange of GDP for GTP on Ras
|
| gptkbp:regulates |
gptkb:MAPK/ERK_pathway
Ras GTPase activity |
| gptkbp:relatedTo |
gptkb:cancer
oncogenesis |
| gptkbp:bfsParent |
gptkb:RAPGEF91
|
| gptkbp:bfsLayer |
7
|