|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
RAB7
Ras-related protein Rab-7a
|
|
gptkbp:associatedWith
|
gptkb:Charcot-Marie-Tooth_disease_type_2B
hereditary sensory and autonomic neuropathy type 1C
|
|
gptkbp:biologicalProcess
|
GTPase activity
autophagy
endocytosis
phagosome maturation
|
|
gptkbp:cellularComponent
|
lysosome membrane
late endosome membrane
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodedBy
|
gptkb:RAB7A_gene
|
|
gptkbp:Entrez_Gene_ID
|
7879
ENSG00000137692
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:function
|
autophagosome-lysosome fusion
late endosome maturation
regulation of endo-lysosomal trafficking
|
|
gptkbp:gene
|
RAB7A
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:9778
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAB7A (human)
|
|
gptkbp:interactsWith
|
gptkb:FYCO1
gptkb:RILP
ORP1L
VPS13C
|
|
gptkbp:length
|
207
|
|
gptkbp:locatedOnChromosome
|
3
3q21.3
|
|
gptkbp:molecularWeight
|
23.6 kDa
|
|
gptkbp:mutationAssociatedWith
|
causes axonal neuropathy
impairs endosome trafficking
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Rab7a
|
|
gptkbp:orthologInYeast
|
Ypt7
|
|
gptkbp:pathway
|
autophagy pathway
endocytosis pathway
|
|
gptkbp:PDB
|
1T91
1VG8
|
|
gptkbp:postTranslationalModification
|
prenylation
phosphorylation
|
|
gptkbp:regulates
|
endosome-lysosome fusion
lysosomal biogenesis
degradation of endocytosed material
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
membrane-bound
|
|
gptkbp:UniProtID
|
gptkb:P51149
|
|
gptkbp:bfsParent
|
gptkb:Rab7
|
|
gptkbp:bfsLayer
|
7
|