|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PKM1
gptkb:PKM2
Cytosolic pyruvate kinase
muscle-type pyruvate kinase
pyruvate kinase isozymes M1/M2
|
|
gptkbp:alternativeSplicing
|
gptkb:PKM2_isoform
PKM1 isoform
|
|
gptkbp:associatedWith
|
gptkb:Warburg_effect
|
|
gptkbp:catalyzes
|
conversion of phosphoenolpyruvate to pyruvate
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:EC_number
|
2.7.1.40
|
|
gptkbp:encodedBy
|
gptkb:PKM_gene
|
|
gptkbp:Entrez_Gene_ID
|
5315
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart muscle
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
other tissues
brain tissue
|
|
gptkbp:gene
|
gptkb:PKM
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Pyruvate kinase, muscle
|
|
gptkbp:involves
|
glycolysis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15q23
|
|
gptkbp:molecularWeight
|
~58 kDa
|
|
gptkbp:OMIM
|
609981
|
|
gptkbp:PDB
|
gptkb:1T5A
|
|
gptkbp:produces
|
gptkb:ATP
|
|
gptkbp:regulates
|
gptkb:ATP
gptkb:fructose_1,6-bisphosphate
phosphorylation
alanine
|
|
gptkbp:significance
|
cancer metabolism
pyruvate kinase deficiency
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P14618
|
|
gptkbp:bfsParent
|
gptkb:PKM
|
|
gptkbp:bfsLayer
|
7
|