Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
myeloproliferative neoplasm |
| gptkbp:affects |
bone marrow
|
| gptkbp:characterizedBy |
gptkb:anemia
splenomegaly extramedullary hematopoiesis bone marrow fibrosis leukoerythroblastosis |
| gptkbp:complication |
gptkb:acute_myeloid_leukemia
infections portal hypertension |
| gptkbp:diagnosedBy |
genetic testing
bone marrow biopsy blood smear |
| gptkbp:firstDescribed |
1951
|
| gptkbp:hasEpidemiology |
1-2 per 100,000 per year
|
| gptkbp:hasOrphanetID |
ORPHA:732
|
| gptkbp:hasPathologyFinding |
osteosclerosis
bone marrow fibrosis megakaryocyte proliferation reticulin fibrosis teardrop-shaped red blood cells |
| https://www.w3.org/2000/01/rdf-schema#label |
Primary Myelofibrosis
|
| gptkbp:ICD-10_code |
D47.4
|
| gptkbp:inheritance |
sporadic
|
| gptkbp:medianAge |
65 years
|
| gptkbp:MeSH_ID |
D009196
|
| gptkbp:mortalityRate |
high
|
| gptkbp:mutationAssociatedWith |
gptkb:JAK2_gene
CALR gene MPL gene |
| gptkbp:OMIM |
254450
|
| gptkbp:onset |
adulthood
|
| gptkbp:prevalence |
rare
|
| gptkbp:prognosis |
variable
|
| gptkbp:riskFactor |
male sex
older age exposure to toxins |
| gptkbp:symptom |
fatigue
weight loss night sweats abdominal discomfort |
| gptkbp:synonym |
agnogenic myeloid metaplasia
chronic idiopathic myelofibrosis idiopathic myelofibrosis |
| gptkbp:treatment |
gptkb:fedratinib
gptkb:ruxolitinib gptkb:hydroxyurea gptkb:allogeneic_stem_cell_transplantation |
| gptkbp:bfsParent |
gptkb:PMF
|
| gptkbp:bfsLayer |
6
|