Paroxysmal Nocturnal Hemoglobinuria
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
|
| gptkbp:abbreviation |
gptkb:PNH
|
| gptkbp:affects |
red blood cells
bone marrow |
| gptkbp:associatedWith |
aplastic anemia
myelodysplastic syndrome |
| gptkbp:causedBy |
mutation in PIGA gene
|
| gptkbp:complication |
renal failure
pulmonary embolism |
| gptkbp:diagnosedBy |
gptkb:Ham's_test
flow cytometry |
| gptkbp:firstDescribed |
gptkb:William_Gull
1882 |
| gptkbp:hasBiomarker |
gptkb:CD55
gptkb:CD59 |
| gptkbp:ICD-10_code |
D59.5
|
| gptkbp:inheritance |
acquired
|
| gptkbp:MeSH_ID |
D010474
|
| gptkbp:OMIM |
300818
|
| gptkbp:pathology |
complement-mediated lysis
deficiency of GPI-anchored proteins |
| gptkbp:prevalence |
rare
|
| gptkbp:symptom |
gptkb:anemia
abdominal pain fatigue thrombosis hemoglobinuria |
| gptkbp:treatment |
gptkb:eculizumab
gptkb:ravulizumab bone marrow transplant |
| gptkbp:bfsParent |
gptkb:PNH
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
Paroxysmal Nocturnal Hemoglobinuria
|