Paroxysmal Nocturnal Hemoglobinuria

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:abbreviation gptkb:PNH
gptkbp:affects red blood cells
bone marrow
gptkbp:associatedWith aplastic anemia
myelodysplastic syndrome
gptkbp:causedBy mutation in PIGA gene
gptkbp:complication renal failure
pulmonary embolism
gptkbp:diagnosedBy gptkb:Ham's_test
flow cytometry
gptkbp:firstDescribed gptkb:William_Gull
1882
gptkbp:hasBiomarker gptkb:CD55
gptkb:CD59
https://www.w3.org/2000/01/rdf-schema#label Paroxysmal Nocturnal Hemoglobinuria
gptkbp:ICD-10_code D59.5
gptkbp:inheritance acquired
gptkbp:MeSH_ID D010474
gptkbp:OMIM 300818
gptkbp:pathology complement-mediated lysis
deficiency of GPI-anchored proteins
gptkbp:prevalence rare
gptkbp:symptom gptkb:anemia
abdominal pain
fatigue
thrombosis
hemoglobinuria
gptkbp:treatment gptkb:eculizumab
gptkb:ravulizumab
bone marrow transplant
gptkbp:bfsParent gptkb:PNH
gptkbp:bfsLayer 6