Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:disease
|
| gptkbp:affects |
red blood cells
impact on quality of life risk of complications variable prognosis |
| gptkbp:associated_with |
thrombosis
bone marrow failure |
| gptkbp:caused_by |
mutation in PIGA gene
|
| gptkbp:clinical_trial |
ongoing studies
thrombocytopenia leukopenia extravasation of hemoglobin intravascular hemolysis |
| gptkbp:complication |
pulmonary hypertension
increased risk of infections renal failure iron deficiency anemia |
| gptkbp:condition |
gptkb:myelodysplastic_syndromes
aplastic anemia |
| gptkbp:diagnosis |
blood tests
flow cytometry clinical history flow cytometry results laboratory findings |
| gptkbp:educational_resources |
gptkb:literature
patient guides |
| gptkbp:financial_support |
PNH patient organizations
|
| gptkbp:first_described_by |
by Paul Strickland
|
| gptkbp:form |
gptkb:Paroxysmal_Nocturnal_Hemoglobinuria
|
| gptkbp:gender |
more common in females
|
| gptkbp:historical_significance |
first recognized in 1882
|
| https://www.w3.org/2000/01/rdf-schema#label |
PNH
|
| gptkbp:inherits_from |
acquired mutation
|
| gptkbp:is_monitored_by |
hemoglobin levels
blood counts thrombosis risk |
| gptkbp:patient_population |
gptkb:children
adults |
| gptkbp:premiered_on |
20-40 years
|
| gptkbp:prevalence |
1-2 per million
|
| gptkbp:research_focus |
gptkb:gene_therapy
new medications |
| gptkbp:risk_factor |
autoimmune diseases
viral infections exposure to certain chemicals previous bone marrow disorders |
| gptkbp:symptoms |
fatigue
hydration abdominal pain pain relief anticoagulation therapy hemolysis dark urine |
| gptkbp:treatment |
gptkb:eculizumab
supportive care bone marrow transplant manage symptoms prevent thrombosis reduce hemolysis |
| gptkbp:bfsParent |
gptkb:Phnom_Penh_International_Airport
|
| gptkbp:bfsLayer |
6
|