|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:protectin
|
|
gptkbp:antibodyTarget
|
used in immunohistochemistry
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:CD59_gene
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
endothelial cells
erythrocytes
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
inhibits membrane attack complex
regulates complement system
|
|
gptkbp:gene
|
gptkb:CD59_gene
|
|
gptkbp:HGNC_ID
|
1680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD59
|
|
gptkbp:inhibitedBy
|
C9 polymerization
complement-mediated cell lysis
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~20 kDa
|
|
gptkbp:OMIM
|
107271
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:relatedTo
|
gptkb:autoimmune_hemolytic_anemia
gptkb:paroxysmal_nocturnal_hemoglobinuria
complement system
|
|
gptkbp:significance
|
involved in autoimmune diseases
deficiency causes paroxysmal nocturnal hemoglobinuria
|
|
gptkbp:structure
|
glycosylphosphatidylinositol (GPI)-anchored protein
|
|
gptkbp:UniProtID
|
P13987
|
|
gptkbp:bfsParent
|
gptkb:PNH
|
|
gptkbp:bfsLayer
|
6
|