Pancreatic Adenocarcinoma

URI: https://gptkb.org/entity/Pancreatic_Adenocarcinoma

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cancer gptkb:disease
gptkbp:affectsOrgan	Pancreas
gptkbp:alternativeName	PDAC Pancreatic ductal adenocarcinoma
gptkbp:firstDescribed	1930s
gptkbp:has5YearSurvivalRate	<10%
gptkbp:hasDiagnosticMethod	gptkb:CT_scan MRI Biopsy Endoscopic ultrasound
gptkbp:hasEpidemiology	More common in males Incidence increases with age
gptkbp:hasICD9Code	157
gptkbp:hasMetastasisSite	gptkb:Peritoneum Liver Lung Lymph nodes
gptkbp:hasMortalityRank	One of the leading causes of cancer death
gptkbp:hasPrecursorLesion	gptkb:MCN IPMN PanIN
gptkbp:hasTumorMarker	gptkb:CEA CA 19-9
gptkbp:hasTypicalAgeOfOnset	>60 years
gptkbp:histology	Glandular
https://www.w3.org/2000/01/rdf-schema#label	Pancreatic Adenocarcinoma
gptkbp:ICD-10_code	C25
gptkbp:isMostCommonTypeOf	gptkb:Pancreatic_cancer
gptkbp:mutationAssociatedWith	gptkb:KRAS gptkb:SMAD4 gptkb:CDKN2A gptkb:TP53
gptkbp:originatedIn	Exocrine pancreas
gptkbp:prognosis	Poor
gptkbp:riskFactor	gptkb:Diabetes_mellitus Smoking Obesity Family history Chronic pancreatitis
gptkbp:stageName	gptkb:TNM
gptkbp:subspecies	gptkb:Pancreatic_cancer
gptkbp:symptom	Weight loss Jaundice Abdominal pain Loss of appetite
gptkbp:treatment	radiation therapy Surgery Chemotherapy
gptkbp:bfsParent	gptkb:PAAD
gptkbp:bfsLayer	8