Pancreatic Adenocarcinoma

URI: https://gptkb.org/entity/Pancreatic_Adenocarcinoma
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:cancer
gptkb:disease
gptkbp:affectsOrgan Pancreas
gptkbp:alternativeName PDAC
Pancreatic ductal adenocarcinoma
gptkbp:firstDescribed 1930s
gptkbp:has5YearSurvivalRate <10%
gptkbp:hasDiagnosticMethod gptkb:CT_scan
MRI
Biopsy
Endoscopic ultrasound
gptkbp:hasEpidemiology More common in males
Incidence increases with age
gptkbp:hasICD9Code 157
gptkbp:hasMetastasisSite gptkb:Peritoneum
Liver
Lung
Lymph nodes
gptkbp:hasMortalityRank One of the leading causes of cancer death
gptkbp:hasPrecursorLesion gptkb:MCN
IPMN
PanIN
gptkbp:hasTumorMarker gptkb:CEA
CA 19-9
gptkbp:hasTypicalAgeOfOnset >60 years
gptkbp:histology Glandular
gptkbp:ICD-10_code C25
gptkbp:isMostCommonTypeOf gptkb:Pancreatic_cancer
gptkbp:mutationAssociatedWith gptkb:KRAS
gptkb:SMAD4
gptkb:CDKN2A
gptkb:TP53
gptkbp:originatedIn Exocrine pancreas
gptkbp:prognosis Poor
gptkbp:riskFactor gptkb:Diabetes_mellitus
Smoking
Obesity
Family history
Chronic pancreatitis
gptkbp:stageName gptkb:TNM
gptkbp:subspecies gptkb:Pancreatic_cancer
gptkbp:symptom Weight loss
Jaundice
Abdominal pain
Loss of appetite
gptkbp:treatment gptkb:radiation_therapy
Surgery
Chemotherapy
gptkbp:bfsParent gptkb:PAAD
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label Pancreatic Adenocarcinoma