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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:DNA_polymerase_theta
gptkb:POLQ
|
|
gptkbp:alternativeName
|
gptkb:DNA_polymerase_theta
gptkb:POLQ
|
|
gptkbp:associatedWith
|
gptkb:cancer
genome stability
|
|
gptkbp:discoveredBy
|
Seki et al.
|
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gptkbp:encodes
|
gptkb:DNA_polymerase_theta
|
|
gptkbp:Entrez_Gene_ID
|
10721
ENSG00000105835
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:firstDescribed
|
1999
|
|
gptkbp:function
|
DNA repair
translesion DNA synthesis
microhomology-mediated end joining
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POLQ gene
|
|
gptkbp:length
|
2590 amino acids
|
|
gptkbp:locatedOnChromosome
|
3q13.31
|
|
gptkbp:mutationAssociatedWith
|
genomic instability
increased sensitivity to DNA damaging agents
|
|
gptkbp:OMIM
|
601802
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila mus308
Mus musculus Polq
|
|
gptkbp:overexpressedIn
|
poor prognosis in cancer
|
|
gptkbp:pathway
|
base excision repair
DNA double-strand break repair
|
|
gptkbp:proteinFamily
|
A-family DNA polymerase
|
|
gptkbp:significance
|
potential target in cancer therapy
|
|
gptkbp:UniProtID
|
gptkb:Q9H9Q4
|
|
gptkbp:bfsParent
|
gptkb:helicase,_POLQ-like
|
|
gptkbp:bfsLayer
|
7
|