Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
uPAR
CD87 |
| gptkbp:associatedWith |
cell migration
cancer metastasis fibrinolysis tissue remodeling |
| gptkbp:discoveredBy |
Wun TC et al.
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodes |
urokinase plasminogen activator surface receptor
|
| gptkbp:Entrez_Gene_ID |
5329
ENSG00000011422 |
| gptkbp:expressedIn |
endothelial cells
immune cells tumor cells |
| gptkbp:function |
involved in cell signaling
binds urokinase-type plasminogen activator regulates pericellular proteolysis |
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasPseudogene |
PLAURP1
|
| gptkbp:HGNC_ID |
gptkb:HGNC:9053
|
| https://www.w3.org/2000/01/rdf-schema#label |
PLAUR gene
|
| gptkbp:interactsWith |
gptkb:integrins
gptkb:plasminogen_activator_inhibitor-1 vitronectin |
| gptkbp:length |
335 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
19q13.31-q13.32 |
| gptkbp:location |
gptkb:cell_membrane
GPI-anchored |
| gptkbp:mutationAssociatedWith |
cancer progression
inflammatory diseases |
| gptkbp:OMIM |
191725
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Plaur
|
| gptkbp:pathway |
immune response
cell adhesion extracellular matrix organization plasminogen activation pathway |
| gptkbp:product |
uPAR
three LU domains |
| gptkbp:proteinReferenceSequence |
NP_002650
|
| gptkbp:referenceGenome |
NM_002659
|
| gptkbp:regulates |
upregulated by cytokines
regulated by transcription factors |
| gptkbp:significance |
biomarker for cancer
target for anti-cancer therapy |
| gptkbp:UniProtID |
Q03405
|
| gptkbp:bfsParent |
gptkb:FOXP2_gene
|
| gptkbp:bfsLayer |
8
|