Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
biochemical and genetic studies
|
| gptkbp:domain |
gptkb:FATC_domain
gptkb:FAT_domain PI3K/PI4K kinase domain |
| gptkbp:evolvesFrom |
related to PI3K family
|
| gptkbp:fullName |
phosphatidylinositol 3-kinase-related kinase family proteins
|
| gptkbp:function |
regulation of cell growth
regulation of metabolism serine/threonine protein kinases regulation of cellular responses to DNA damage |
| https://www.w3.org/2000/01/rdf-schema#label |
PIKK family proteins
|
| gptkbp:inhibitedBy |
small molecule inhibitors (e.g., KU-55933 for ATM, rapamycin for mTOR)
|
| gptkbp:member |
gptkb:ATR
gptkb:DNA-PKcs gptkb:mTOR ATM TRRAP PIKK-like protein 1 SMG1 |
| gptkbp:molecularWeight |
large (>250 kDa)
|
| gptkbp:organism |
eukaryotes
|
| gptkbp:relatedTo |
DNA repair
cell cycle control nonsense-mediated mRNA decay translation regulation |
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:bfsParent |
gptkb:FATC_domain
gptkb:TOR_Loop_3 |
| gptkbp:bfsLayer |
8
|