Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
phosphatidylinositol (4,5)-bisphosphate |
| gptkbp:database |
InterPro: IPR001849
Pfam: PF00169 |
| gptkbp:discoveredBy |
gptkb:Richard_A._Anderson
|
| gptkbp:domain |
Pleckstrin homology domain
|
| gptkbp:example |
gptkb:Akt
gptkb:Dynamin gptkb:Phospholipase_C Bruton's tyrosine kinase |
| gptkbp:firstDescribed |
1993
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
membrane localization
bind phosphoinositides |
| https://www.w3.org/2000/01/rdf-schema#label |
PH domain proteins
|
| gptkbp:involves |
vesicle trafficking
cell signaling cytoskeletal organization |
| gptkbp:number_of_amino_acids_in_domain |
~120
|
| gptkbp:structure |
gptkb:beta-sandwich
C-terminal alpha helix |
| gptkbp:bfsParent |
gptkb:PIP3
|
| gptkbp:bfsLayer |
7
|