|
gptkbp:instanceOf
|
gptkb:protein
guanine nucleotide exchange factor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:James_E._Rothman
gptkb:Sandra_L._Schmid
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
gptkb:pleckstrin_homology_domain
GTPase domain
GTPase effector domain
proline-rich domain
|
|
gptkbp:encodedBy
|
gptkb:DNM1_gene
gptkb:DNM2_gene
gptkb:DNM3_gene
|
|
gptkbp:family
|
gptkb:dynamin_superfamily
|
|
gptkbp:form
|
helical polymers
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
vesicle trafficking
endocytosis
membrane scission
|
|
gptkbp:hasIsoform
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dynamin
|
|
gptkbp:interactsWith
|
gptkb:SNX9
gptkb:amphiphysin
gptkb:endophilin
gptkb:syndapin
|
|
gptkbp:involvedIn
|
clathrin-mediated endocytosis
mitochondrial division
synaptic vesicle recycling
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Charcot-Marie-Tooth_disease
gptkb:centronuclear_myopathy
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_shibire
|
|
gptkbp:PDB
|
3SNH
|
|
gptkbp:regulates
|
membrane fission
|
|
gptkbp:requires
|
GTP hydrolysis
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
Cell
|
|
gptkbp:UniProtID
|
gptkb:Q05193
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|