Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:receptor_tyrosine_kinase
gptkb:protein |
| gptkbp:alternativeName |
P2X7 receptor
|
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases chronic pain neuroinflammation |
| gptkbp:discoveredBy |
gptkb:Geoffrey_Burnstock
|
| gptkbp:encodedBy |
P2RX7 gene
|
| gptkbp:enemyOf |
Brilliant Blue G
oxidized ATP |
| gptkbp:expressedIn |
gptkb:microglia
macrophages immune cells lymphocytes |
| gptkbp:foundIn |
gptkb:human
gptkb:mouse right |
| gptkbp:function |
involved in inflammation
ATP-gated ion channel mediates cell death |
| https://www.w3.org/2000/01/rdf-schema#label |
P2Z receptor
|
| gptkbp:ligand |
gptkb:ATP
|
| gptkbp:location |
gptkb:plasma_membrane
|
| gptkbp:OMIM |
602566
|
| gptkbp:permeableTo |
cations
large molecules (upon prolonged activation) |
| gptkbp:relatedTo |
purinergic signaling
|
| gptkbp:structure |
trimeric
|
| gptkbp:UniProtID |
Q99572
|
| gptkbp:bfsParent |
gptkb:P2RX7
|
| gptkbp:bfsLayer |
7
|