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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:IL-8
gptkb:Monocyte-derived_neutrophil_chemotactic_factor
gptkb:Neutrophil_chemotactic_factor
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gptkbp:biologicalProcess
|
gptkb:Inflammatory_response
Chemotaxis
Cytokine activity
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gptkbp:database
|
gptkb:UniProt
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gptkbp:disulfideBond
|
Yes
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gptkbp:Entrez_Gene_ID
|
3576
ENSG00000169429
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gptkbp:function
|
Attracts neutrophils, basophils, and T-cells
Plays a role in inflammation
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gptkbp:gene
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gptkb:CXCL8
|
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gptkbp:GO
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gptkb:GO:0008009_(chemokine_activity)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
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gptkbp:HGNC_ID
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6025
|
|
https://www.w3.org/2000/01/rdf-schema#label
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P20963
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gptkbp:lastAnnotationUpdate
|
2021-02-10
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gptkbp:latestReleaseVersion
|
1990-01-01
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gptkbp:length
|
99 amino acids
|
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gptkbp:locatedOnChromosome
|
4
|
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gptkbp:mass
|
11 kDa
|
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gptkbp:name
|
IL8_HUMAN
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
gptkb:Mouse:_Cxcl1
Rat: Cxcl1
|
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gptkbp:pathway
|
gptkb:Cytokine-cytokine_receptor_interaction
Chemokine signaling pathway
|
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gptkbp:PDB
|
1IL8
3IL8
|
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gptkbp:postTranslationalModification
|
N-terminal processed
|
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gptkbp:protein_name
|
gptkb:Interleukin-8
|
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gptkbp:refersTo
|
gptkb:Interleukin-8
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gptkbp:RefSeq
|
NP_000575.1
|
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gptkbp:reviewedBy
|
gptkb:Swiss-Prot
|
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gptkbp:sequenceStatus
|
Reviewed
|
|
gptkbp:sequenceVersion
|
1
|
|
gptkbp:signalPeptide
|
Yes
|
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gptkbp:significance
|
Biomarker for infection and inflammation
Involved in inflammatory diseases
|
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gptkbp:species
|
gptkb:Homo_sapiens
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gptkbp:structure
|
Monomer, can form dimers
|
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gptkbp:subcellularLocation
|
Secreted
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gptkbp:tissue_specificity
|
Expressed in many tissues, especially immune cells
|
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gptkbp:UniProtID
|
gptkb:P20963
|
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gptkbp:bfsParent
|
gptkb:CD247_gene
gptkb:CD3_zeta_chain
gptkb:T-cell_receptor_complex
gptkb:CD3Z
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gptkbp:bfsLayer
|
7
|