|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Pyruvate_kinase_PKM
gptkb:Pyruvate_kinase_isozymes_M1/M2
|
|
gptkbp:associatedWith
|
gptkb:cancer
pyruvate kinase deficiency
|
|
gptkbp:biologicalProcess
|
glycolytic process
pyruvate kinase activity
|
|
gptkbp:catalyzes
|
ATP + pyruvate ⇌ ADP + phosphoenolpyruvate
|
|
gptkbp:cofactor
|
K+
Mg2+
|
|
gptkbp:encodedBy
|
PKM gene (human)
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000335181
|
|
gptkbp:enzymeCommissionNumber
|
2.7.1.40
|
|
gptkbp:expressedIn
|
high in brain
high in muscle
variable in other tissues
|
|
gptkbp:function
|
catalyzes the final step of glycolysis
|
|
gptkbp:GO_term
|
GO:0006096
GO:0004743
|
|
gptkbp:hasIsoform
|
gptkb:PKM1
gptkb:PKM2
|
|
gptkbp:HGNC_ID
|
9021
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P11958 (human PKM)
|
|
gptkbp:InterPro
|
IPR001697
|
|
gptkbp:KEGGID
|
hsa:5315
|
|
gptkbp:length
|
531 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q23
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:OMIM
|
609937
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse PKM
rat PKM
zebrafish PKM
|
|
gptkbp:PDB
|
gptkb:3GR4
gptkb:1T5A
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:proteinFamily
|
PF00224
|
|
gptkbp:Reactome
|
gptkb:R-HSA-70263
|
|
gptkbp:RefSeq
|
gptkb:NP_002645.3
|
|
gptkbp:subcellularLocation
|
cytosol
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:tissue_specificity
|
expressed in muscle, brain, and other tissues
|
|
gptkbp:UniGene
|
Hs.654682
|
|
gptkbp:UniProtID
|
P11958
|
|
gptkbp:bfsParent
|
gptkb:Pyruvate_kinase
|
|
gptkbp:bfsLayer
|
7
|