|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
Alcohol-induced liver disease
Cancer susceptibility
|
|
gptkbp:biologicalProcess
|
xenobiotic metabolic process
|
|
gptkbp:cellularComponent
|
endoplasmic reticulum membrane
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:discoveredBy
|
1987
|
|
gptkbp:ensembl
|
ENSG00000130649
|
|
gptkbp:Entrez_Gene_ID
|
1571
|
|
gptkbp:enzymeCommissionNumber
|
1.14.14.1
|
|
gptkbp:function
|
Monooxygenase involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids
|
|
gptkbp:gene
|
CYP2E1
|
|
gptkbp:goMolecularFunction
|
monooxygenase activity
|
|
gptkbp:hasPolymorphism
|
Genetic polymorphisms affect enzyme activity
|
|
gptkbp:HGNC_ID
|
2597
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P07195
|
|
gptkbp:inducedBy
|
gptkb:acetone
ethanol
|
|
gptkbp:length
|
493 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
|
|
gptkbp:location
|
10q26.3
|
|
gptkbp:molecularWeight
|
56,841 Da
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Cyp2e1
rat Cyp2e1
|
|
gptkbp:pathway
|
Drug metabolism - cytochrome P450
Metabolism of xenobiotics by cytochrome P450
|
|
gptkbp:products
|
2 isoforms by alternative splicing
|
|
gptkbp:protein_name
|
Cytochrome P450 2E1
|
|
gptkbp:RefSeq
|
NP_000763.2
|
|
gptkbp:sequenceStatus
|
Reviewed (Swiss-Prot)
|
|
gptkbp:structure
|
Contains a cytochrome P450 domain
|
|
gptkbp:subcellularLocation
|
gptkb:Endoplasmic_reticulum
Microsome
|
|
gptkbp:tissue_specificity
|
Liver
Kidney
Lung
|
|
gptkbp:UniProt_entry_name
|
CYP2E1_HUMAN
|
|
gptkbp:UniProtID
|
gptkb:P07195
|
|
gptkbp:bfsParent
|
gptkb:LDHB
|
|
gptkbp:bfsLayer
|
7
|