Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
small molecule
MDM2 inhibitor |
| gptkbp:CASNumber |
675576-98-4
|
| gptkbp:chemicalFormula |
C30H30Cl2N4O4
|
| gptkbp:clinicalTrialPhase |
preclinical
|
| gptkbp:developedBy |
gptkb:Hoffmann-La_Roche
|
| gptkbp:discoveredBy |
2004
|
| gptkbp:effect |
induces apoptosis in cancer cells
activates p53 pathway causes cell cycle arrest |
| https://www.w3.org/2000/01/rdf-schema#label |
Nutlin-3a
|
| gptkbp:isomerOf |
gptkb:Nutlin-3b
|
| gptkbp:IUPACName |
4-[(4,5-dihydro-4,4,5,5-tetramethyl-1,3-dioxo-2H-imidazol-2-yl)amino]-2-(4-chlorophenyl)-2-oxo-N-(4-chlorophenyl)acetamide
|
| gptkbp:mechanismOfAction |
inhibits MDM2-p53 interaction
|
| gptkbp:molecularWeight |
581.49 g/mol
|
| gptkbp:PubChem_CID |
216345
CHEMBL1213105 |
| gptkbp:synonym |
gptkb:Nutlin-3
cis-Nutlin-3 |
| gptkbp:target |
gptkb:MDM2
gptkb:p53 |
| gptkbp:used_in |
cancer research
|
| gptkbp:bfsParent |
gptkb:nutlin-3
|
| gptkbp:bfsLayer |
7
|