New Delhi metallo-beta-lactamase

URI: https://gptkb.org/entity/New_Delhi_metallo-beta-lactamase
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:NDM
gptkbp:cofactor zinc
gptkbp:detects molecular diagnostics
PCR
gptkbp:discoveredBy Yong et al.
gptkbp:discoveredIn 2008
gptkbp:enzymeClassification metallo-beta-lactamase
gptkbp:firstIsolatedFrom gptkb:Klebsiella_pneumoniae
gptkbp:firstPatientOrigin gptkb:India
gptkbp:firstReported gptkb:Sweden
gptkbp:foundIn gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa
gptkb:Acinetobacter_baumannii
gptkbp:gene blaNDM
gptkbp:globalSpread worldwide
https://www.w3.org/2000/01/rdf-schema#label New Delhi metallo-beta-lactamase
gptkbp:inhibitedBy none (no clinically effective inhibitors as of 2024)
gptkbp:mechanismOfAction hydrolyzes beta-lactam antibiotics
gptkbp:namedAfter gptkb:New_Delhi
gptkbp:notableVariant gptkb:NDM-1
gptkb:NDM-5
gptkb:NDM-7
gptkbp:publicHealthConcern antibiotic resistance
gptkbp:resistanceProfile broad-spectrum beta-lactam resistance
gptkbp:resistantTo carbapenem antibiotics
gptkbp:spreadTo plasmids
gptkbp:treatmentChallenge limited antibiotic options
gptkbp:bfsParent gptkb:antimicrobial_resistance_gene_NDM
gptkb:NDM_beta-lactamase
gptkb:NDM-type_metallo-beta-lactamases
gptkbp:bfsLayer 8