New Delhi metallo-beta-lactamase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	gptkb:NDM
gptkbp:cofactor	zinc
gptkbp:detects	molecular diagnostics PCR
gptkbp:discoveredBy	Yong et al.
gptkbp:discoveredIn	2008
gptkbp:enzymeClassification	gptkb:metallo-beta-lactamase
gptkbp:firstIsolatedFrom	gptkb:Klebsiella_pneumoniae
gptkbp:firstPatientOrigin	gptkb:India
gptkbp:firstReported	gptkb:Sweden
gptkbp:foundIn	gptkb:Enterobacteriaceae gptkb:Pseudomonas_aeruginosa gptkb:Acinetobacter_baumannii
gptkbp:gene	blaNDM
gptkbp:globalSpread	worldwide
gptkbp:inhibitedBy	none (no clinically effective inhibitors as of 2024)
gptkbp:mechanismOfAction	hydrolyzes beta-lactam antibiotics
gptkbp:namedAfter	gptkb:New_Delhi
gptkbp:notableVariant	gptkb:NDM-1 gptkb:NDM-5 gptkb:NDM-7
gptkbp:publicHealthConcern	antibiotic resistance
gptkbp:resistanceProfile	broad-spectrum beta-lactam resistance
gptkbp:resistantTo	carbapenem antibiotics
gptkbp:spreadTo	plasmids
gptkbp:treatmentChallenge	limited antibiotic options
gptkbp:bfsParent	gptkb:antimicrobial_resistance_gene_NDM gptkb:NDM_beta-lactamase gptkb:NDM-type_metallo-beta-lactamases
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	New Delhi metallo-beta-lactamase