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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
|
Negative factor
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gptkbp:conservedIn
|
variable among HIV strains
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gptkbp:discoveredIn
|
1986
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gptkbp:encodedBy
|
gptkb:nef_gene
|
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gptkbp:foundIn
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gptkb:HIV-1
gptkb:HIV-2
|
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gptkbp:function
|
downregulation of CD4
downregulation of MHC I
enhancement of viral infectivity
modulation of T cell signaling
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gptkbp:interactsWith
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gptkb:PI3K
gptkb:AP-2_complex
gptkb:PACS-1
gptkb:Src_family_kinases
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gptkbp:length
|
206 amino acids (HIV-1)
|
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gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
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gptkbp:locatedOnChromosome
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gptkb:HIV_genome
|
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gptkbp:molecularWeight
|
27-35 kDa
|
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gptkbp:notEssentialFor
|
viral replication in vitro
|
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gptkbp:postTranslationalModification
|
myristoylation
|
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gptkbp:requires
|
high viral load in vivo
|
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gptkbp:roleInPathogenesis
|
immune evasion
AIDS progression
|
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gptkbp:structure
|
contains SH3-binding domain
contains acidic cluster
contains proline-rich region
|
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gptkbp:target
|
host immune response
|
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gptkbp:bfsParent
|
gptkb:NEF
|
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nef protein (HIV)
|