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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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Negative factor
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gptkbp:conservedIn
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variable among HIV strains
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gptkbp:discoveredIn
|
1986
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gptkbp:encodedBy
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gptkb:nef_gene
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gptkbp:foundIn
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gptkb:HIV-1
gptkb:HIV-2
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gptkbp:function
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downregulation of CD4
downregulation of MHC I
enhancement of viral infectivity
modulation of T cell signaling
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https://www.w3.org/2000/01/rdf-schema#label
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Nef protein (HIV)
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gptkbp:interactsWith
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gptkb:PI3K
gptkb:AP-2_complex
gptkb:PACS-1
gptkb:Src_family_kinases
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gptkbp:length
|
206 amino acids (HIV-1)
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gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:locatedOnChromosome
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gptkb:HIV_genome
|
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gptkbp:molecularWeight
|
27-35 kDa
|
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gptkbp:notEssentialFor
|
viral replication in vitro
|
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gptkbp:postTranslationalModification
|
myristoylation
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gptkbp:requires
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high viral load in vivo
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gptkbp:roleInPathogenesis
|
immune evasion
AIDS progression
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gptkbp:structure
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contains SH3-binding domain
contains acidic cluster
contains proline-rich region
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gptkbp:target
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host immune response
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gptkbp:bfsParent
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gptkb:NEF
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gptkbp:bfsLayer
|
8
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