|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
beta-naphthoflavone
|
|
gptkbp:alias
|
DT-diaphorase
NAD(P)H:quinone oxidoreductase 1
|
|
gptkbp:associatedWith
|
cancer susceptibility
benzene toxicity
|
|
gptkbp:cofactor
|
gptkb:FAD
|
|
gptkbp:discoveredBy
|
Ernesto Carafoli (enzyme activity)
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:encodes
|
NAD(P)H dehydrogenase [quinone] 1
|
|
gptkbp:Entrez_Gene_ID
|
1728
ENSG00000181019
|
|
gptkbp:enzymeCommissionNumber
|
1.6.5.2
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
liver
colon
|
|
gptkbp:fullName
|
NAD(P)H quinone dehydrogenase 1
|
|
gptkbp:function
|
protection against oxidative stress
detoxification of quinones
|
|
gptkbp:GO_term
|
GO:0008113
|
|
gptkbp:HGNC_ID
|
HGNC:2877
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NQO1
|
|
gptkbp:inhibitedBy
|
gptkb:dicoumarol
chloroquine
|
|
gptkbp:length
|
274 amino acids
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:molecularWeight
|
30 kDa
|
|
gptkbp:mutationAssociatedWith
|
reduced enzyme activity
NQO1*2 (C609T, Pro187Ser)
|
|
gptkbp:OMIM
|
125860
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Nqo1
|
|
gptkbp:pathway
|
Drug metabolism - cytochrome P450
Metabolism of xenobiotics by cytochrome P450
KEGG: hsa:1728
|
|
gptkbp:PDB
|
1D4A
|
|
gptkbp:regulates
|
induced by oxidative stress
regulated by Nrf2
|
|
gptkbp:significance
|
biomarker for cancer
pharmacogenomics marker
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:substrate
|
gptkb:menadione
gptkb:mitomycin_C
quinones
|
|
gptkbp:UniProtID
|
P15559
|
|
gptkbp:bfsParent
|
gptkb:NQO
|
|
gptkbp:bfsLayer
|
8
|