Multiple System Atrophy (MSA)
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
neurodegenerative disease
|
| gptkbp:abbreviation |
gptkb:MSA
|
| gptkbp:affects |
movement
balance autonomic nervous system blood pressure regulation bladder function |
| gptkbp:cause |
unknown
|
| gptkbp:diagnosedBy |
clinical evaluation
neurological examination MRI autonomic testing |
| gptkbp:firstDescribed |
1960s
|
| gptkbp:gender |
slightly more common in men
|
| gptkbp:hasOrphanetID |
gptkb:ORPHA:211
|
| https://www.w3.org/2000/01/rdf-schema#label |
Multiple System Atrophy (MSA)
|
| gptkbp:ICD-10_code |
G90.3
|
| gptkbp:medianSurvival |
6 to 10 years after onset
|
| gptkbp:MeSH_ID |
D020754
|
| gptkbp:MSA-C |
predominant cerebellar ataxia
|
| gptkbp:MSA-P |
predominant parkinsonism
|
| gptkbp:OMIM |
146500
|
| gptkbp:onset |
adulthood
|
| gptkbp:pathology |
alpha-synuclein accumulation
glial cytoplasmic inclusions |
| gptkbp:prevalence |
rare
3-5 per 100,000 people |
| gptkbp:prognosis |
progressive
fatal |
| gptkbp:relatedTo |
gptkb:Parkinson's_disease
gptkb:progressive_supranuclear_palsy Lewy body dementia |
| gptkbp:riskFactor |
male sex
age over 50 |
| gptkbp:subspecies |
gptkb:MSA-C
gptkb:MSA-P |
| gptkbp:symptom |
gptkb:orthostatic_hypotension
tremor difficulty swallowing erectile dysfunction parkinsonism slurred speech urinary incontinence muscle rigidity cerebellar ataxia autonomic failure |
| gptkbp:treatment |
physical therapy
symptomatic management medications for blood pressure medications for parkinsonism |
| gptkbp:bfsParent |
gptkb:MSA-C
|
| gptkbp:bfsLayer |
8
|