|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:alsoKnownAs
|
gptkb:RU-486
|
|
gptkbp:approvalYear
|
2000
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
G03XB01
|
|
gptkbp:availableOn
|
many countries worldwide
|
|
gptkbp:brand
|
gptkb:Korlym
Mifeprex
|
|
gptkbp:CASNumber
|
gptkb:84371-65-3
|
|
gptkbp:category
|
antiglucocorticoid
antiprogestogen
abortifacient
steroid hormone antagonist
|
|
gptkbp:chemicalClass
|
gptkb:Corticosteroid
|
|
gptkbp:chemicalFormula
|
steroidal
|
|
gptkbp:contraindication
|
ectopic pregnancy
chronic adrenal failure
|
|
gptkbp:developedBy
|
gptkb:France
Émile-Étienne Baulieu
|
|
gptkbp:discoveredBy
|
Roussel Uclaf
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:eliminationHalfLife
|
18-25 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:form
|
gptkb:tablet
|
|
gptkbp:hasMolecularFormula
|
gptkb:C29H35NO2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mifepristone
|
|
gptkbp:includedIn
|
United States REMS program
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1987
|
|
gptkbp:mechanismOfAction
|
glucocorticoid receptor antagonist
progesterone receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notableLegalStatus
|
subject to legal and political controversy in some countries
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
X (contraindicated in pregnancy except for abortion)
|
|
gptkbp:pregnancyRisk
|
causes abortion
|
|
gptkbp:prescribes
|
hyperglycemia secondary to Cushing's syndrome
termination of intrauterine pregnancy up to 10 weeks
|
|
gptkbp:prescriptionRequired
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
fatigue
vaginal bleeding
|
|
gptkbp:usedFor
|
gptkb:Cushing's_syndrome
gptkb:misoprostol
medical abortion
labor induction
management of miscarriage
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Corticosteroid
|
|
gptkbp:bfsLayer
|
6
|