Methylguanine-DNA methyltransferase

URI: https://gptkb.org/entity/Methylguanine-DNA_methyltransferase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:MGMT
gptkbp:alternativeName O6-alkylguanine-DNA alkyltransferase
O6-methylguanine-DNA methyltransferase
gptkbp:associatedWith gptkb:glioblastoma
colorectal cancer
gptkbp:cofactor none
gptkbp:discoveredBy 1970s
gptkbp:EC_number 2.1.1.63
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:function DNA repair
removal of alkyl groups from O6-guanine in DNA
gptkbp:gene gptkb:MGMT
gptkbp:gene_ID_(human) 4255
gptkbp:GO_term GO:0003907
https://www.w3.org/2000/01/rdf-schema#label Methylguanine-DNA methyltransferase
gptkbp:inhibitedBy O6-benzylguanine
gptkbp:locatedOnChromosome chromosome 10q26
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:mechanismOfAction suicide enzyme
gptkbp:molecularWeight 21 kDa
gptkbp:PDB 1QNT
gptkbp:regulates promoter methylation
gptkbp:significance chemoresistance to alkylating agents
gptkbp:structure single polypeptide chain
gptkbp:substrate O4-methylthymine
O6-methylguanine
gptkbp:UniProtID P16455
gptkbp:bfsParent gptkb:MBGT
gptkbp:bfsLayer 7