Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
metalloproteinase
metalloendopeptidase |
| gptkbp:catalyzes |
hydrolysis of peptide bonds
|
| gptkbp:cofactor |
metal ion
|
| gptkbp:commonCofactor |
zinc
cobalt |
| gptkbp:EC_number |
3.4.24.-
|
| gptkbp:foundIn |
gptkb:Bacteria
animals fungi plants |
| gptkbp:function |
protein degradation
extracellular matrix remodeling regulation of biological processes |
| https://www.w3.org/2000/01/rdf-schema#label |
Metalloprotease
|
| gptkbp:inhibitedBy |
gptkb:EDTA
chelating agents 1,10-phenanthroline |
| gptkbp:significance |
arthritis
cancer progression bacterial pathogenesis |
| gptkbp:structure |
active site contains metal ion
often contains HEXXH motif |
| gptkbp:subclassOf |
gptkb:matrix_metalloproteinase
thermolysin ADAM protease astacin |
| gptkbp:bfsParent |
gptkb:Peptidase
|
| gptkbp:bfsLayer |
7
|