Medullary thyroid carcinoma

URI: https://gptkb.org/entity/Medullary_thyroid_carcinoma
GPTKB entity
Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Neuroendocrine Tumor
gptkbp:affects thyroid gland
gptkbp:associatedWith gptkb:Multiple_Endocrine_Neoplasia_type_2A
gptkb:Multiple_Endocrine_Neoplasia_type_2B
RET proto-oncogene mutation
gptkbp:canBeFamilial true
gptkbp:canBePartOfSyndrome gptkb:MEN2A
gptkb:MEN2B
FMTC (Familial Medullary Thyroid Carcinoma)
gptkbp:canBeSporadic true
gptkbp:canMetastasizeTo gptkb:cancer
gptkb:bone
liver
lymph nodes
gptkbp:canOccurAtAnyAge true
gptkbp:commonIn females
gptkbp:diagnosedBy genetic testing
calcitonin measurement
fine needle aspiration
RET mutation testing
gptkbp:firstDescribed 1959
https://www.w3.org/2000/01/rdf-schema#label Medullary thyroid carcinoma
gptkbp:ICD-10_code gptkb:C73
gptkbp:marking gptkb:calcitonin
gptkb:carcinoembryonic_antigen
gptkbp:medianAge 50 years
gptkbp:MeSH_ID D013964
gptkbp:notResponsiveTo radioactive iodine
TSH suppression therapy
gptkbp:OMIM 155240
gptkbp:originatedIn parafollicular C cells
gptkbp:prevalenceAmongThyroidCancers 3-5%
gptkbp:prognosis variable
gptkbp:riskFactor gptkb:MEN2_syndrome
family history
gptkbp:secretes gptkb:calcitonin
gptkb:ACTH
gptkb:CEA
serotonin
gptkbp:symptom diarrhea
weight loss
hoarseness
flushing
dysphagia
neck mass
metastatic symptoms
gptkbp:treatment thyroidectomy
lymph node dissection
gptkbp:UMLS_CUI C0027750
gptkbp:bfsParent gptkb:chromosome_10
gptkb:Thyroid_Neoplasms
gptkb:Parafollicular_cells
gptkbp:bfsLayer 6