|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MT2
Melatonin receptor type 1B
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
melatonin receptor 1B
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000170421
4544
|
|
gptkbp:expressedIn
|
gptkb:pancreatic_islets
|
|
gptkbp:function
|
regulation of insulin secretion
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:7477
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MTNR1B gene
|
|
gptkbp:length
|
362 amino acids
|
|
gptkbp:ligand
|
gptkb:melatonin
|
|
gptkbp:locatedOnChromosome
|
11q21-q22
|
|
gptkbp:mutationAssociatedWith
|
increased risk of type 2 diabetes
|
|
gptkbp:OMIM
|
600804
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Mtnr1b
|
|
gptkbp:pathway
|
melatonin signaling pathway
|
|
gptkbp:product
|
gptkb:MT2_receptor
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
glucose homeostasis
circadian rhythm
|
|
gptkbp:significance
|
genetic risk factor for diabetes
|
|
gptkbp:tissue_specificity
|
brain
retina
pancreas
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
P49286
|
|
gptkbp:bfsParent
|
gptkb:MT2_receptor
|
|
gptkbp:bfsLayer
|
7
|