|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MT2
Mel1b
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
|
|
gptkbp:biologicalProcess
|
circadian rhythm
G protein-coupled receptor activity
regulation of insulin secretion
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Reppert SM et al.
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodes
|
Melatonin receptor type 1B protein
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000170421
4544
|
|
gptkbp:expressedIn
|
gptkb:pancreatic_islets
brain
retina
|
|
gptkbp:fullName
|
melatonin receptor 1B
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
melatonin receptor activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:7462
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MTNR1B
|
|
gptkbp:length
|
362 amino acids
|
|
gptkbp:locatedOnChromosome
|
11
11q21-q22
|
|
gptkbp:mutationAssociatedWith
|
impaired glucose tolerance
increased fasting glucose
|
|
gptkbp:OMIM
|
600804
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
insulin secretion
|
|
gptkbp:relatedTo
|
gptkb:MTNR1A
MTNR1C
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:type
|
inhibits adenylate cyclase activity
|
|
gptkbp:UniProtID
|
Q13585
|
|
gptkbp:bfsParent
|
gptkb:MT2_receptor
gptkb:melatonin_receptors
|
|
gptkbp:bfsLayer
|
7
|