|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
oral route
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
N04BA01
|
|
gptkbp:bioavailability
|
30% (with carbidopa)
|
|
gptkbp:brand
|
gptkb:Madopar
gptkb:Parcopa
gptkb:Sinemet
|
|
gptkbp:CASNumber
|
59-92-7
|
|
gptkbp:category
|
antiparkinsonian agent
dopaminergic agent
prodrug
amino acid derivative
catecholamine
neurotransmitter precursor
|
|
gptkbp:chemicalFormula
|
C9H11NO4
|
|
gptkbp:combines
|
benserazide
carbidopa
|
|
gptkbp:contraindication
|
narrow-angle glaucoma
malignant melanoma
|
|
gptkbp:discoveredBy
|
gptkb:Arvid_Carlsson
|
|
gptkbp:discoveredIn
|
1911
|
|
gptkbp:eliminationHalfLife
|
1.5 hours
|
|
gptkbp:foundIn
|
gptkb:Mucuna_pruriens
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Levodopa
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:MeSH_ID
|
gptkb:D007981
|
|
gptkbp:metabolism
|
aromatic L-amino acid decarboxylase
|
|
gptkbp:molecularWeight
|
197.19 g/mol
|
|
gptkbp:predecessor
|
dopamine
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL50
gptkb:CHEBI:15765
gptkb:DB01235
6047
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
nausea
vomiting
dyskinesia
hallucinations
|
|
gptkbp:UNII
|
46627O600J
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
dopamine-responsive dystonia
|
|
gptkbp:bfsParent
|
gptkb:D010141
gptkb:Idiopathic_Parkinson's_Disease
gptkb:N04BB01
|
|
gptkbp:bfsLayer
|
7
|