|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:activeIngredient
|
gptkb:levodopa
carbidopa
|
|
gptkbp:approvedBy
|
1975
|
|
gptkbp:ATCCode
|
N04BA02
|
|
gptkbp:contraindication
|
narrow-angle glaucoma
MAO inhibitor use
|
|
gptkbp:drugClass
|
antiparkinsonian agent
|
|
gptkbp:eliminationHalfLife
|
1-2 hours (levodopa)
1-2 hours (carbidopa)
|
|
gptkbp:FDAApproved
|
yes
|
|
gptkbp:form
|
gptkb:tablet
extended-release tablet
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sinemet
|
|
gptkbp:interactsWith
|
gptkb:MAO_inhibitors
antipsychotic drugs
antihypertensive drugs
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Merck_&_Co.
|
|
gptkbp:mechanismOfAction
|
dopaminergic agent
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescribes
|
gptkb:dopa-responsive_dystonia_(off-label)
gptkb:restless_legs_syndrome_(off-label)
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
nausea
insomnia
dyskinesia
hallucinations
|
|
gptkbp:tradeNameOf
|
gptkb:carbidopa/levodopa
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
parkinsonism
|
|
gptkbp:bfsParent
|
gptkb:L-3,4-dihydroxyphenylalanine
|
|
gptkbp:bfsLayer
|
7
|