Idiopathic Parkinson's Disease
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
Neurodegenerative disease
Parkinson's disease subtype |
| gptkbp:associatedWith |
LRRK2 mutation
SNCA mutation |
| gptkbp:causedBy |
unknown
|
| gptkbp:complication |
gptkb:dementia
Falls Depression Dysphagia Autonomic dysfunction |
| gptkbp:diagnosedBy |
Clinical assessment
Response to dopaminergic therapy |
| gptkbp:distinctFrom |
Atypical Parkinsonism
Secondary Parkinsonism |
| gptkbp:firstDescribed |
James Parkinson, 1817
|
| gptkbp:hasEpidemiology |
More common in men
|
| gptkbp:hasNonMotorSymptoms |
Depression
Constipation Sleep disturbances Cognitive impairment Anosmia Autonomic dysfunction |
| https://www.w3.org/2000/01/rdf-schema#label |
Idiopathic Parkinson's Disease
|
| gptkbp:ICD-10_code |
gptkb:G20
|
| gptkbp:onset |
Usually after age 60
|
| gptkbp:pathology |
Lewy bodies
Loss of dopaminergic neurons in substantia nigra |
| gptkbp:prevalence |
1% of people over 60
|
| gptkbp:prognosis |
Progressive
|
| gptkbp:progression |
Gradual
|
| gptkbp:riskFactor |
Age
Family history Male gender |
| gptkbp:symptom |
gptkb:Micrographia
gptkb:Tremor Resting tremor Bradykinesia Masked facies Muscle rigidity Postural instability Shuffling gait |
| gptkbp:synonym |
gptkb:Parkinson's_disease
gptkb:Primary_Parkinsonism |
| gptkbp:treatment |
gptkb:Levodopa
MAO-B inhibitors Physical therapy Deep brain stimulation Dopamine agonists |
| gptkbp:bfsParent |
gptkb:Atypical_Parkinsonian_Syndromes
|
| gptkbp:bfsLayer |
6
|