Large Granular Lymphocytic Leukemia

URI: https://gptkb.org/entity/Large_Granular_Lymphocytic_Leukemia
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:leukemia
gptkb:lymphoproliferative_disorder
gptkb:disease
gptkbp:affects gptkb:natural_killer_cells
gptkb:T-cells
large granular lymphocytes
gptkbp:associatedWith autoimmune disorders
rheumatoid arthritis
gptkbp:diagnosedBy bone marrow biopsy
blood smear
flow cytometry
gptkbp:firstDescribed 1985
gptkbp:gender slightly more common in males
gptkbp:ICD-10_code gptkb:C91.8
gptkbp:medianAge 60 years
gptkbp:mutationAssociatedWith gptkb:STAT3_mutation
gptkb:STAT5b_mutation
gptkbp:prevalence rare
gptkbp:prognosis gptkb:chronic_disease
indolent course
gptkbp:subspecies gptkb:T-cell_large_granular_lymphocytic_leukemia
gptkb:chronic_NK-cell_lymphocytosis
gptkbp:symptom gptkb:anemia
splenomegaly
neutropenia
recurrent infections
gptkbp:treatment gptkb:cyclophosphamide
gptkb:cyclosporine
gptkb:methotrexate
immunosuppressive therapy
gptkbp:bfsParent gptkb:LGL_Leukemia
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Large Granular Lymphocytic Leukemia