Large Granular Lymphocytic Leukemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:leukemia gptkb:lymphoproliferative_disorder gptkb:disease
gptkbp:affects	gptkb:natural_killer_cells gptkb:T-cells large granular lymphocytes
gptkbp:associatedWith	autoimmune disorders rheumatoid arthritis
gptkbp:diagnosedBy	bone marrow biopsy blood smear flow cytometry
gptkbp:firstDescribed	1985
gptkbp:gender	slightly more common in males
gptkbp:ICD-10_code	gptkb:C91.8
gptkbp:medianAge	60 years
gptkbp:mutationAssociatedWith	gptkb:STAT3_mutation gptkb:STAT5b_mutation
gptkbp:prevalence	rare
gptkbp:prognosis	gptkb:chronic_disease indolent course
gptkbp:subspecies	gptkb:T-cell_large_granular_lymphocytic_leukemia gptkb:chronic_NK-cell_lymphocytosis
gptkbp:symptom	gptkb:anemia splenomegaly neutropenia recurrent infections
gptkbp:treatment	gptkb:cyclophosphamide gptkb:cyclosporine gptkb:methotrexate immunosuppressive therapy
gptkbp:bfsParent	gptkb:LGL_Leukemia
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Large Granular Lymphocytic Leukemia