Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
transcription factor
nuclear receptor |
| gptkbp:activatedBy |
oxysterols
|
| gptkbp:affiliatedWith |
gptkb:nuclear_receptor_subfamily_1_group_H
|
| gptkbp:binds |
oxysterols
|
| gptkbp:discoveredBy |
1990s
|
| gptkbp:encodedBy |
gptkb:NR1H2
gptkb:NR1H3 |
| gptkbp:expressedIn |
liver
macrophages intestine |
| gptkbp:formsHeterodimerWith |
gptkb:retinoid_X_receptor_(RXR)
|
| https://www.w3.org/2000/01/rdf-schema#label |
LXR (liver X receptor)
|
| gptkbp:regulates |
gptkb:ABCA1
gptkb:ABCG1 gptkb:CYP7A1 gptkb:SREBP-1c lipid metabolism inflammation cholesterol metabolism |
| gptkbp:subspecies |
LXRα (NR1H3)
LXRβ (NR1H2) |
| gptkbp:target |
atherosclerosis therapy
metabolic disease therapy |
| gptkbp:bfsParent |
gptkb:ABCG1
|
| gptkbp:bfsLayer |
7
|