L1 cell adhesion molecule

URI: https://gptkb.org/entity/L1_cell_adhesion_molecule
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
cell surface receptor
gptkbp:alternativeName gptkb:CD171
gptkb:Neural_cell_adhesion_molecule_L1
gptkb:L1CAM
gptkbp:associatedWith gptkb:MASA_syndrome
gptkb:X-linked_hydrocephalus
gptkb:spastic_paraplegia_type_1
CRASH syndrome
gptkbp:category gptkb:immunoglobulin_superfamily
transmembrane protein
gptkbp:discoveredBy gptkb:M._Schachner
gptkbp:discoveredIn 1984
gptkbp:encodedBy gptkb:L1CAM_gene
gptkbp:expressedIn gptkb:nervous_system
gptkb:kidney
intestine
gptkbp:foundIn humans
mice
other vertebrates
gptkbp:function neurite outgrowth
axon guidance
cell-cell adhesion
neuronal migration
gptkbp:gene gptkb:L1CAM
gptkbp:HGNC_ID HGNC:6526
https://www.w3.org/2000/01/rdf-schema#label L1 cell adhesion molecule
gptkbp:interactsWith gptkb:FGFR1
gptkb:integrins
gptkb:ankyrin
neurofascin
contactin
gptkbp:locatedOnChromosome gptkb:Xq28
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight ~200-220 kDa
gptkbp:mutationAssociatedWith neurological disorders
gptkbp:OMIM 308840
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:role cancer progression
immune response
learning and memory
tumor metastasis
gptkbp:structure immunoglobulin-like domains
fibronectin type III domains
gptkbp:subcellularLocation gptkb:plasma_membrane
gptkbp:UniProtID P32004
gptkbp:bfsParent gptkb:L1CAM
gptkbp:bfsLayer 7