L1 cell adhesion molecule

URI: https://gptkb.org/entity/L1_cell_adhesion_molecule

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:cell_surface_receptor
gptkbp:alternativeName	gptkb:CD171 gptkb:Neural_cell_adhesion_molecule_L1 gptkb:L1CAM
gptkbp:associatedWith	gptkb:MASA_syndrome gptkb:X-linked_hydrocephalus gptkb:spastic_paraplegia_type_1 CRASH syndrome
gptkbp:category	gptkb:immunoglobulin_superfamily transmembrane protein
gptkbp:discoveredBy	gptkb:M._Schachner
gptkbp:discoveredIn	1984
gptkbp:encodedBy	gptkb:L1CAM_gene
gptkbp:expressedIn	gptkb:nervous_system gptkb:kidney intestine
gptkbp:foundIn	humans mice other vertebrates
gptkbp:function	neurite outgrowth axon guidance cell-cell adhesion neuronal migration
gptkbp:gene	gptkb:L1CAM
gptkbp:HGNC_ID	HGNC:6526
gptkbp:interactsWith	gptkb:FGFR1 gptkb:integrins gptkb:ankyrin neurofascin contactin
gptkbp:locatedOnChromosome	gptkb:Xq28
gptkbp:location	gptkb:cell_membrane
gptkbp:molecularWeight	~200-220 kDa
gptkbp:mutationAssociatedWith	neurological disorders
gptkbp:OMIM	308840
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:role	gptkb:immune_response cancer progression learning and memory tumor metastasis
gptkbp:structure	immunoglobulin-like domains fibronectin type III domains
gptkbp:subcellularLocation	gptkb:plasma_membrane
gptkbp:UniProtID	P32004
gptkbp:bfsParent	gptkb:L1CAM
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	L1 cell adhesion molecule