|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:K2C8
gptkb:CK8
Cytokeratin 8
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:liver_disease
inflammatory bowel disease
|
|
gptkbp:clinicalTrialPhase
|
immunohistochemistry for epithelial tumors
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
Keratin, type II cytoskeletal 8
|
|
gptkbp:Entrez_Gene_ID
|
3856
ENSG00000170421
|
|
gptkbp:expressedIn
|
embryonic development
epithelial tissues
|
|
gptkbp:function
|
structural component of intermediate filaments in epithelial cells
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple transcript variants
|
|
gptkbp:HGNC_ID
|
HGNC:6446
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRT8 gene
|
|
gptkbp:interactsWith
|
gptkb:KRT18_gene
desmoplakin
KRT19 gene
|
|
gptkbp:length
|
511 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.13
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause liver dysfunction
can increase susceptibility to apoptosis
|
|
gptkbp:OMIM
|
148060
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Krt8
|
|
gptkbp:pathway
|
cell differentiation
cytoskeleton organization
apoptosis regulation
|
|
gptkbp:proteinFamily
|
type II keratins
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
regulated by transcription factors
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P05787
|
|
gptkbp:usedAsMarker
|
epithelial cell marker
|
|
gptkbp:bfsParent
|
gptkb:cytokeratin_8
|
|
gptkbp:bfsLayer
|
8
|