|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CK18
K18
Cytokeratin 18
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:liver_disease
cirrhosis
non-alcoholic steatohepatitis
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
Keratin 18 protein
|
|
gptkbp:Entrez_Gene_ID
|
3875
ENSG00000111077
|
|
gptkbp:expressedIn
|
embryonic development
epithelial tissues
adult life
|
|
gptkbp:function
|
structural component of intermediate filaments in epithelial cells
|
|
gptkbp:hasBiomarker
|
apoptosis
liver injury
epithelial cell death
|
|
gptkbp:hasTranscriptVariant
|
KRT18-201
KRT18-202
|
|
gptkbp:HGNC_ID
|
HGNC:6446
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRT18 gene
|
|
gptkbp:interactsWith
|
gptkb:plakoglobin
gptkb:KRT8_gene
desmoplakin
|
|
gptkbp:length
|
430 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.13
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:mutationAssociatedWith
|
inflammatory bowel disease
liver fibrosis
|
|
gptkbp:OMIM
|
148070
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Krt18
|
|
gptkbp:pathway
|
cell cycle regulation
apoptosis signaling
keratinization
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
caspase cleavage
|
|
gptkbp:proteinFamily
|
gptkb:type_I_keratin
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
cell proliferation
cell apoptosis
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
nucleus (during apoptosis)
|
|
gptkbp:UniProtID
|
P05783
|
|
gptkbp:bfsParent
|
gptkb:cytokeratin_18
|
|
gptkbp:bfsLayer
|
8
|