|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
JARID1B
PLU-1
RBP2-H1
|
|
gptkbp:associatedWith
|
gptkb:cancer
melanoma
prostate cancer
|
|
gptkbp:discoveredBy
|
Barrett et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:domain
|
gptkb:JmjN_domain
JmjC domain
PHD finger
ARID domain
|
|
gptkbp:encodedBy
|
KDM5B gene
|
|
gptkbp:Entrez_Gene_ID
|
10765
ENSG00000142583
|
|
gptkbp:expressedIn
|
gptkb:testis
brain
breast tissue
|
|
gptkbp:function
|
histone demethylase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:20857
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KDM5B
|
|
gptkbp:inhibitedBy
|
CPI-455
GSK-J1
|
|
gptkbp:interactsWith
|
gptkb:pRB
gptkb:REST
gptkb:HDAC1
gptkb:histone_H3
|
|
gptkbp:involvedIn
|
epigenetic regulation
transcriptional repression
|
|
gptkbp:length
|
1544 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 1
1q32.1
|
|
gptkbp:memberOf
|
Jumonji C (JmjC) domain-containing proteins
|
|
gptkbp:molecularWeight
|
175 kDa
|
|
gptkbp:mutationAssociatedWith
|
intellectual disability
developmental delay
|
|
gptkbp:orthologInMouse
|
Kdm5b
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
stem cell self-renewal
|
|
gptkbp:removesMethylGroupFrom
|
H3K4me3
H3K4me2
|
|
gptkbp:UniProtID
|
O15054
|
|
gptkbp:bfsParent
|
gptkb:ZNF217
gptkb:SIN3A
|
|
gptkbp:bfsLayer
|
8
|