|
gptkbp:instanceOf
|
gptkb:protein
hormone
|
|
gptkbp:administeredBy
|
gptkb:insulin
injection
subcutaneous injection
intravenous injection
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:CASNumber
|
11061-68-0
|
|
gptkbp:category
|
gptkb:pharmacy
biochemistry
endocrinology
metabolism
|
|
gptkbp:chain
|
A chain
B chain
|
|
gptkbp:deficiencyCauses
|
gptkb:diabetes_mellitus
|
|
gptkbp:discoveredBy
|
gptkb:Frederick_Banting
gptkb:Charles_Best
|
|
gptkbp:discoveredIn
|
1921
|
|
gptkbp:encodedBy
|
gptkb:INS_gene
|
|
gptkbp:firstRecombinantMarketed
|
1982
|
|
gptkbp:firstRecombinantProduced
|
1978
|
|
gptkbp:firstSynthesizedInLab
|
1963
|
|
gptkbp:halfLife
|
4-6 minutes
|
|
gptkbp:hasAminoAcids
|
51
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Insulin, human
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:inhibitedBy
|
lipolysis
glycogenolysis
gluconeogenesis
|
|
gptkbp:isAllergen
|
yes
|
|
gptkbp:isApprovedDrug
|
yes
|
|
gptkbp:linkedBy
|
disulfide bonds
|
|
gptkbp:marketedAs
|
gptkb:Humulin
gptkb:Novolin
|
|
gptkbp:molecularWeight
|
5808 Da
|
|
gptkbp:PDB
|
1ZNJ
|
|
gptkbp:predecessor
|
preproinsulin
proinsulin
|
|
gptkbp:producedBy
|
pancreas
beta cells
|
|
gptkbp:promotion
|
glucose uptake
fat storage
glycogen synthesis
|
|
gptkbp:recipient
|
gptkb:insulin_receptor
|
|
gptkbp:regulates
|
blood glucose
|
|
gptkbp:requires
|
glucose homeostasis
|
|
gptkbp:structureType
|
peptide
|
|
gptkbp:UNII
|
1F7A44V6OU
|
|
gptkbp:UniProtID
|
P01308
|
|
gptkbp:usedFor
|
treatment of diabetes mellitus
|
|
gptkbp:bfsParent
|
gptkb:DB00005
|
|
gptkbp:bfsLayer
|
7
|