Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:discoveredIn |
1982
|
| gptkbp:encodedBy |
gptkb:IL4_gene
|
| gptkbp:enemyOf |
gptkb:dupilumab
gptkb:pitrakinra |
| gptkbp:Entrez_Gene_ID |
3565
|
| gptkbp:expressedIn |
gptkb:cancer
spleen lymphoid tissues |
| gptkbp:function |
induces class switching to IgE
inhibits Th1 cell differentiation promotes Th2 cell differentiation stimulates B cell proliferation |
| gptkbp:gene |
gptkb:IL4
|
| gptkbp:HGNC_ID |
6014
|
| https://www.w3.org/2000/01/rdf-schema#label |
Il-4
|
| gptkbp:inducedBy |
IgE production
IgG1 production VCAM-1 expression |
| gptkbp:inhibitedBy |
IFN-gamma production
Th1 cell development macrophage pro-inflammatory cytokine production |
| gptkbp:involvedIn |
asthma
allergic response immune regulation |
| gptkbp:length |
153 amino acids
|
| gptkbp:locatedOnChromosome |
chromosome 5q31.1
|
| gptkbp:molecularWeight |
15 kDa
|
| gptkbp:OMIM |
147780
|
| gptkbp:orthologInMouse |
gptkb:Il4
|
| gptkbp:producedBy |
gptkb:basophils
gptkb:mast_cells activated T cells |
| gptkbp:promotion |
B cell differentiation
CD23 expression MHC class II expression |
| gptkbp:recipient |
gptkb:IL-4_receptor
|
| gptkbp:regulates |
fibrosis
macrophage activation antibody production eosinophil migration |
| gptkbp:structure |
four-helix bundle
|
| gptkbp:target |
allergy therapies
biologic drugs for asthma |
| gptkbp:UniProtID |
P05112
|
| gptkbp:bfsParent |
gptkb:Soviet_Air_Force
|
| gptkbp:bfsLayer |
5
|