|
gptkbp:instanceOf
|
gptkb:monoclonal_antibody
|
|
gptkbp:abbreviation
|
gptkb:Immunoglobulin_E
|
|
gptkbp:binds
|
gptkb:basophils
gptkb:mast_cells
gptkb:FcεRI_receptor
|
|
gptkbp:classSwitching
|
gptkb:B_cells
|
|
gptkbp:discoveredBy
|
gptkb:Kimishige_Ishizaka
gptkb:Teruko_Ishizaka
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:elevatedIn
|
gptkb:atopic_dermatitis
asthma
parasitic infections
allergic diseases
|
|
gptkbp:foundIn
|
mammals
|
|
gptkbp:fullName
|
gptkb:Immunoglobulin_E
|
|
gptkbp:function
|
mediates allergic reactions
defense against parasitic infections
|
|
gptkbp:gene
|
IGH constant epsilon gene
|
|
gptkbp:halfLife
|
2-3 days
|
|
gptkbp:heavyChainType
|
epsilon
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IgE
|
|
gptkbp:locatedOnChromosome
|
chromosome 14 (IGH locus)
|
|
gptkbp:measures
|
immunoassay
|
|
gptkbp:medicalUse
|
diagnosis of allergies
identifying parasitic infection
monitoring allergic disease
|
|
gptkbp:normalSerumLevel
|
<150 IU/mL
|
|
gptkbp:presentIn
|
serum
mucosal tissues
|
|
gptkbp:producedBy
|
plasma cells
|
|
gptkbp:promotion
|
gptkb:IL-4
gptkb:IL-13
histamine release
inflammatory mediators
|
|
gptkbp:relatedTo
|
gptkb:eczema
gptkb:hay_fever
immunotherapy
anaphylaxis
allergic rhinitis
food allergy
|
|
gptkbp:role
|
Type I hypersensitivity
defense against helminths
immediate allergic response
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:target
|
gptkb:omalizumab
anti-IgE therapy
|
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_E_(IgE)
|
|
gptkbp:bfsLayer
|
6
|