Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
histamine release
degranulation |
| gptkbp:alsoKnownAs |
high-affinity IgE receptor
|
| gptkbp:category |
immunology
cell surface receptor |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:expressedIn |
gptkb:Langerhans_cells
eosinophils (in some conditions) |
| gptkbp:foundIn |
gptkb:basophils
gptkb:mast_cells |
| gptkbp:function |
binds IgE antibody
mediates allergic responses |
| gptkbp:gene |
gptkb:FCER1A
gptkb:FCER1B gptkb:FCER1G |
| https://www.w3.org/2000/01/rdf-schema#label |
FcεRI receptor
|
| gptkbp:involvedIn |
gptkb:atopic_dermatitis
asthma allergic rhinitis type I hypersensitivity |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:OMIM |
147139
|
| gptkbp:structure |
tetrameric (αβγ2) in humans
trimeric (αγ2) in some cells |
| gptkbp:subunit |
alpha chain
beta chain gamma chain |
| gptkbp:target |
anti-allergy drugs
|
| gptkbp:UniProtID |
P12319 (alpha chain)
P14061 (beta chain) P30273 (gamma chain) |
| gptkbp:bfsParent |
gptkb:IGE
gptkb:immunoglobulin_E_(IgE) |
| gptkbp:bfsLayer |
6
|