Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
DNA-binding inhibitor proteins
Inhibitor of differentiation proteins |
| gptkbp:biologicalProcess |
cell differentiation
cell proliferation angiogenesis neurogenesis tumorigenesis |
| gptkbp:discoveredBy |
V. Benezra
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:feature |
contain a helix-loop-helix (HLH) domain
lack a DNA-binding domain |
| gptkbp:fullName |
Inhibitor of DNA binding proteins
|
| gptkbp:function |
regulation of transcription
inhibition of basic helix-loop-helix (bHLH) transcription factors |
| gptkbp:gene_family_members |
gptkb:ID2
gptkb:ID3 gptkb:ID4 ID1 |
| gptkbp:GO_term |
GO:0003700 (DNA-binding transcription factor activity, RNA polymerase II-specific)
GO:0045595 (regulation of cell differentiation) |
| https://www.w3.org/2000/01/rdf-schema#label |
Id proteins
|
| gptkbp:locatedOnChromosome |
ID1: 20q11
ID2: 2p25 ID3: 1p36 ID4: 6p22 |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
13-20 kDa
|
| gptkbp:organism |
gptkb:human
gptkb:mouse other vertebrates |
| gptkbp:PDB |
1WQ5 (ID2 HLH domain)
|
| gptkbp:regulates |
regulated by hypoxia
regulated by Notch signaling regulated by TGF-beta regulated by BMP signaling |
| gptkbp:relatedTo |
gptkb:E_proteins
bHLH transcription factors |
| gptkbp:role |
gptkb:neuroblastoma
gptkb:Alzheimer's_disease gptkb:cancer gptkb:glioblastoma |
| gptkbp:UniProtID |
ID1: P41134
ID2: Q02363 ID3: Q02535 ID4: Q14469 |
| gptkbp:bfsParent |
gptkb:MyoD
gptkb:E_proteins |
| gptkbp:bfsLayer |
7
|